For infants (less than 1 year old) with repeated vomiting & lack of weigth gain due to reflux (GERD), there are very limited medicines that are available for effective treatment in India.
A relatively new molecule is Esomeprazole marketed in the form of Nexpro Junior Satchets. I was trying to search for the effective dose in a 3 month old in my care who has significant reflux (vomiting, decresed weight gain, opisthotonic posturing etc.)
Here is what I found
Each satchet contains 10 mg of Esomeprazole and hence I have started the baby on 5 mg (1/2 satchets) once a day for the same.
Previously I have been using Junior Lanzol (Lansaprazole) tablets by Cipla, but they are a little difficult to dissolve in water to feed an infant. Hopefully this would be a more acceptable solution for an infant.
A relatively new molecule is Esomeprazole marketed in the form of Nexpro Junior Satchets. I was trying to search for the effective dose in a 3 month old in my care who has significant reflux (vomiting, decresed weight gain, opisthotonic posturing etc.)
Here is what I found
Usual Pediatric Dose for Erosive Esophagitis
Healing:
12 to 17 year olds: 20 or 40 mg once daily
Duration of therapy: 4 to 8 weeks
1 to 11 year olds:
-weight less than 20 kg: 10 mg once daily
-weight greater than or equal to 20 kg: 10 or 20 mg once daily
Duration of therapy: 8 weeks
Comments: Doses over 1 mg/kg/day have not been studied.
Due to acid-mediated GERD:
1 month to less than 1 year old:
-weight 3 kg to 5 kg: 2.5 mg once daily-weight greater than 5 kg to 7.5 kg: 5 mg once daily
-weight greater than 7.5 kg to 12 kg: 10 mg once daily
Duration of therapy: For up to 6 weeks
Comments: Doses over 1.33 mg/kg/day have not been studied.
Read more at http://www.drugs.com/dosage/esomeprazole.html#iukblX6mMgSAPTLx.99
12 to 17 year olds: 20 or 40 mg once daily
Duration of therapy: 4 to 8 weeks
1 to 11 year olds:
-weight less than 20 kg: 10 mg once daily
-weight greater than or equal to 20 kg: 10 or 20 mg once daily
Duration of therapy: 8 weeks
Comments: Doses over 1 mg/kg/day have not been studied.
Due to acid-mediated GERD:
1 month to less than 1 year old:
-weight 3 kg to 5 kg: 2.5 mg once daily-weight greater than 5 kg to 7.5 kg: 5 mg once daily
-weight greater than 7.5 kg to 12 kg: 10 mg once daily
Duration of therapy: For up to 6 weeks
Comments: Doses over 1.33 mg/kg/day have not been studied.
Read more at http://www.drugs.com/dosage/esomeprazole.html#iukblX6mMgSAPTLx.99
Each satchet contains 10 mg of Esomeprazole and hence I have started the baby on 5 mg (1/2 satchets) once a day for the same.
Previously I have been using Junior Lanzol (Lansaprazole) tablets by Cipla, but they are a little difficult to dissolve in water to feed an infant. Hopefully this would be a more acceptable solution for an infant.