Q: I conceived accidentally while my baby is 6 months and being breastfed. I have been advised Misoprostol for abortion. Should I stop Breastfeeding, and for how long?
Ans. Mispoprostol is a prostaglandin E1 analogue. Prostaglandin E1 and other prostaglandins appear normally in colostrum and milk. Misoprostol is rapidly metabolized in the mother to misoprostol acid which is biologically active and is excreted in human breast milk in small quantities. There are no published reports of adverse effects of misoprostol in breast-feeding infants of mothers taking misoprostol. Pharmacokinetic studies reveal that misoprostol is excreted into breast milk with drug levels that rise and fall very quickly. Levels become undetectable within 5 hours of maternal ingestion.1 However, breastfeeding women should be advised that misoprostol may cause infant diarrhea.2 The manufacturer recommends that caution should be exercised when misoprostol is administered to a nursing woman.
However, because of the low levels of misoprostol in breastmilk, amounts ingested by the infant are small and would not be expected to cause any adverse effects in breastfed infants. No special precautions are required.
Given these facts, my recommendation would be to avoid BF for not more than a day after taking Misoprostol, you may give formula milk during this period.
References
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2760893/
http://www.drugs.com/breastfeeding/misoprostol.html
Ans. Mispoprostol is a prostaglandin E1 analogue. Prostaglandin E1 and other prostaglandins appear normally in colostrum and milk. Misoprostol is rapidly metabolized in the mother to misoprostol acid which is biologically active and is excreted in human breast milk in small quantities. There are no published reports of adverse effects of misoprostol in breast-feeding infants of mothers taking misoprostol. Pharmacokinetic studies reveal that misoprostol is excreted into breast milk with drug levels that rise and fall very quickly. Levels become undetectable within 5 hours of maternal ingestion.1 However, breastfeeding women should be advised that misoprostol may cause infant diarrhea.2 The manufacturer recommends that caution should be exercised when misoprostol is administered to a nursing woman.
However, because of the low levels of misoprostol in breastmilk, amounts ingested by the infant are small and would not be expected to cause any adverse effects in breastfed infants. No special precautions are required.
Given these facts, my recommendation would be to avoid BF for not more than a day after taking Misoprostol, you may give formula milk during this period.
References
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2760893/
http://www.drugs.com/breastfeeding/misoprostol.html
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