Chronic constipation is a frequently encountered problem in the paediatric wards and clinics. Your usual line of management has been to prescribe adequate doses of regular lactulose and use sodium picosulphate as a second line laxative or as add on treatment. Recently, you have become aware of a new drug—polyethylene glycol (PEG). As you have not prescribed this drug earlier, you want to appraise the evidence before using it in your clinical practice.
- Ezlax is cheaper - Rs 13 v/s Rs 28 for Laxopeg - prices of MuOUT would be around Rs 16 as per the company rep
- Laxopeg claims direct import of raw material from DOW chemicals USA, leading to better product
- Both Ezlax and Laxopeg are generally well tolerated - Ezlax appears like Fanta (orange drink) while Laxopeg becomes a clear colourless & odourless solution
- Adding electrolytes does not appear to be clinically indicated in managing chronic constipation - since there is no significant electrolyte loss. It possibly makes sense in the surgical or disimpaction procedures where high doses are needed in adults mostly
- Adding electrolytes can possibly lead to electrolyte imbalance
- Adding electrolytes can possibly lead to salty taste, reducing compliance